Unusual solubilization capacity of hydrophobic drug olanzapine in polysorbate micelles for improved sustained drug release

Polysorbates and Pluronic polymers are straightforward to use improve the performance of hydrophobic molecules, however, colloidal systems these not fully understood loading drug molecules in Polysorbate micelles rely on a plethora factors. Thus, it is laborious task select optimal as delivery vehicle. To pave way for Polysorbates, three with different hydrophobicity were selected oral Olanzapine (OLZ). At higher concentration, T20 low accommodated amount OLZ than other T40 T60 hydrophobicity. The effect mixed P84 (T20, T40, T60) solubilization was also studied at concentration ratios found be T20:P84 3:2 %w/v ratio. Stronger interactions between noticed isothermal titration calorimetry (ITC), resulting micelles. Dynamic light scattering (DLS) small angle neutron (SANS) measurements revealed that greater sizes pure polysorbate size decreased after OLZ. Furthermore, SANS suggested decrease aggregation number promoted capacity micelle. exhibited sustained release behavior biological relevant media, examined vitro dialysis method. Therefore, believed finding this work could useful formulations which Pluronics primarily used.